| Termijn | Thuis | Uitteam | Uitslag |
|---|---|---|---|
| 20-5-22 20:45 | FC Turin | AS Rom | 0:3 |
| 21-5-22 17:15 | FC Genua 1893 | FC Bologna | 0:1 |
| 21-5-22 20:45 | Lazio Rom | Hellas Verona | 3:3 |
| 21-5-22 20:45 | AC Florenz | Juventus Turin | 2:0 |
| 21-5-22 20:50 | Atalanta Bergamo | FC Empoli | 0:1 |
| 22-5-22 12:30 | Spezia Calcio | SSC Neapel | 0:3 |
| 22-5-22 18:00 | Sassuolo Calcio | AC Mailand | 0:3 |
| 22-5-22 18:05 | Inter Mailand | Sampdoria Genua | 3:0 |
| 22-5-22 21:00 | US Salernitana | Udinese Calcio | 0:4 |
| 22-5-22 21:00 | Venezia FC | Cagliari Calcio | 0:0 |