| Termijn | Thuis | Uitteam | Uitslag |
|---|---|---|---|
| 22-5-21 20:45 | Cagliari Calcio | FC Genua 1893 | 0:1 |
| 22-5-21 20:45 | FC Crotone | AC Florenz | 0:0 |
| 22-5-21 20:45 | Sampdoria Genua | Parma Calcio 1913 | 3:0 |
| 23-5-21 15:00 | Inter Mailand | Udinese Calcio | 5:1 |
| 23-5-21 20:45 | Spezia Calcio | AS Rom | 2:2 |
| 23-5-21 20:45 | Atalanta Bergamo | AC Mailand | 0:2 |
| 23-5-21 20:45 | FC Bologna | Juventus Turin | 1:4 |
| 23-5-21 20:45 | Sassuolo Calcio | Lazio Rom | 2:0 |
| 23-5-21 20:45 | SSC Neapel | Hellas Verona | 1:1 |
| 23-5-21 20:45 | FC Turin | Benevento Calcio | 1:1 |