| Termijn | Thuis | Uitteam | Uitslag |
|---|---|---|---|
| 21-5-22 16:00 | FK Krasnodar | Achmat Grozny | 1:1 |
| 21-5-22 16:00 | ZSKA Moskau | FK Rostow | 4:0 |
| 21-5-22 16:00 | Dynamo Moskau | PFC Sochi | 1:5 |
| 21-5-22 16:00 | FK Nischni Nowgorod | Zenit St. Petersburg | 1:0 |
| 21-5-22 16:00 | FC Krylia Sovetov Samara | Lokomotive Moskau | 0:1 |
| 21-5-22 16:00 | Rubin Kasan | FK Oefa | 1:2 |
| 21-5-22 16:00 | FK Arsenal Toela | FK Oeral | 1:2 |
| 21-5-22 16:00 | FK Chimki | Spartak Moskau | 2:1 |