| Termijn | Thuis | Uitteam | Uitslag |
|---|---|---|---|
| 16-5-21 13:00 | Dynamo Moskau | ZSKA Moskau | 3:2 |
| 16-5-21 13:00 | FK Oefa | FK Arsenal Toela | 2:1 |
| 16-5-21 13:00 | FC Tambov | Zenit St. Petersburg | 1:5 |
| 16-5-21 13:00 | Rubin Kasan | FK Rotor Volgograd | 1:1 |
| 16-5-21 13:00 | FK Chimki | PFC Sochi | 0:0 |
| 16-5-21 13:00 | Lokomotive Moskau | FK Oeral | 1:0 |
| 16-5-21 13:00 | Achmat Grozny | Spartak Moskau | 2:2 |
| 16-5-21 13:00 | FK Rostow | FK Krasnodar | 1:3 |