| Termijn | Thuis | Uitteam | Uitslag |
|---|---|---|---|
| 22-5-22 17:00 | FC Chelsea | FC Watford | 2:1 |
| 22-5-22 17:00 | Crystal Palace | Manchester United | 1:0 |
| 22-5-22 17:00 | Leicester City | FC Southampton | 4:1 |
| 22-5-22 17:00 | FC Liverpool | Wolverhampton Wanderers | 3:1 |
| 22-5-22 17:00 | Manchester City | Aston Villa | 3:2 |
| 22-5-22 17:00 | Norwich City | Tottenham Hotspur | 0:5 |
| 22-5-22 17:00 | FC Arsenal | FC Everton | 5:1 |
| 22-5-22 17:00 | Brentford FC | Leeds United | 1:2 |
| 22-5-22 17:00 | Brighton and Hove Albion | West Ham United | 3:1 |
| 22-5-22 17:00 | FC Burnley | Newcastle United | 1:2 |