| Termijn | Thuis | Uitteam | Uitslag |
|---|---|---|---|
| 7-5-22 13:30 | Derby County | Cardiff City | 0:1 |
| 7-5-22 13:30 | Swansea City | Queens Park Rangers | 0:1 |
| 7-5-22 13:30 | Sheffield United | FC Fulham | 4:0 |
| 7-5-22 13:30 | FC Stoke City | Coventry City | 1:1 |
| 7-5-22 13:30 | West Bromwich Albion | FC Barnsley | 4:0 |
| 7-5-22 13:30 | Birmingham City | Blackburn Rovers | 1:2 |
| 7-5-22 13:30 | AFC Bournemouth | FC Millwall | 1:0 |
| 7-5-22 13:30 | Huddersfield Town | Bristol City | 2:0 |
| 7-5-22 13:30 | Hull City A.F.C. | Nottingham Forest | 1:1 |
| 7-5-22 13:30 | Luton Town | FC Reading | 1:0 |
| 7-5-22 13:30 | Peterborough United | FC Blackpool | 5:0 |
| 7-5-22 13:30 | Preston North End | FC Middlesbrough | 4:1 |