Speelschema
| Termijn | Voorspellingsdeadline | Thuis | Uitteam | Uitslag | Puntentelling |
|---|---|---|---|---|---|
| 27-8-21 20:30 | 27-8-21 20:30 | Borussia Dortmund | 1899 Hoffenheim | 3:2 | 1 - 3 punten |
| 28-8-21 15:30 | 28-8-21 15:30 | FC Augsburg | Bayer 04 Leverkusen | 1:4 | 1 - 3 punten |
| 28-8-21 15:30 | 28-8-21 15:30 | FSV Mainz 05 | SpVgg Greuther Fürth | 3:0 | 1 - 3 punten |
| 28-8-21 15:30 | 28-8-21 15:30 | VfB Stuttgart | SC Freiburg | 2:3 | 1 - 3 punten |
| 28-8-21 15:30 | 28-8-21 15:30 | 1. FC Köln | VfL Bochum | 2:1 | 1 - 3 punten |
| 28-8-21 15:30 | 28-8-21 15:30 | Arminia Bielefeld | Eintracht Frankfurt | 1:1 | 1 - 3 punten |
| 28-8-21 18:30 | 28-8-21 18:30 | FC Bayern München | Hertha BSC | 5:0 | 1 - 3 punten |
| 29-8-21 15:30 | 29-8-21 15:30 | 1. FC Union Berlin | Bor. Mönchengladbach | 2:1 | 1 - 3 punten |
| 29-8-21 17:30 | 29-8-21 17:30 | VfL Wolfsburg | RB Leipzig | 1:0 | 1 - 3 punten |