| Termijn | Voorspellingsdeadline | Thuis | Uitteam | Uitslag | Puntentelling |
|---|
| 13-8-21 20:30 | 13-8-21 20:00 | Bor. Mönchengladbach | FC Bayern München | 1:1 | 2 - 4 punten |
| 14-8-21 15:30 | 14-8-21 15:00 | VfL Wolfsburg | VfL Bochum | 1:0 | 2 - 4 punten |
| 14-8-21 15:30 | 14-8-21 15:00 | 1. FC Union Berlin | Bayer 04 Leverkusen | 1:1 | 2 - 4 punten |
| 14-8-21 15:30 | 14-8-21 15:00 | VfB Stuttgart | SpVgg Greuther Fürth | 5:1 | 2 - 4 punten |
| 14-8-21 15:30 | 14-8-21 15:00 | FC Augsburg | 1899 Hoffenheim | 0:4 | 2 - 4 punten |
| 14-8-21 15:30 | 14-8-21 15:00 | Arminia Bielefeld | SC Freiburg | 0:0 | 2 - 4 punten |
| 14-8-21 18:30 | 14-8-21 18:00 | Borussia Dortmund | Eintracht Frankfurt | 5:2 | 2 - 4 punten |
| 15-8-21 15:30 | 15-8-21 15:00 | FSV Mainz 05 | RB Leipzig | 1:0 | 2 - 4 punten |
| 15-8-21 17:30 | 15-8-21 17:00 | 1. FC Köln | Hertha BSC | 3:1 | 2 - 4 punten |
