Speelschema
| Termijn | Voorspellingsdeadline | Thuis | Uitteam | Uitslag | Puntentelling |
|---|---|---|---|---|---|
| 27-8-21 18:30 | 27-8-21 18:20 | SV Sandhausen | FC Ingolstadt | 0:2 | 2 - 4 punten |
| 27-8-21 18:30 | 27-8-21 18:20 | 1. FC Nürnberg | Karlsruher SC | 2:1 | 2 - 4 punten |
| 28-8-21 13:30 | 28-8-21 13:20 | Holstein Kiel | Erzgebirge Aue | 3:0 | 2 - 4 punten |
| 28-8-21 13:30 | 28-8-21 13:20 | SV Darmstadt 98 | Hannover 96 | 4:0 | 2 - 4 punten |
| 28-8-21 13:30 | 28-8-21 13:20 | 1. FC Heidenheim 1846 | Hamburger SV | 0:0 | 2 - 4 punten |
| 28-8-21 20:30 | 28-8-21 20:20 | FC Schalke 04 | Fortuna Düsseldorf | 3:1 | 2 - 4 punten |
| 29-8-21 13:30 | 29-8-21 13:20 | Dynamo Dresden | SC Paderborn 07 | 0:3 | 2 - 4 punten |
| 29-8-21 13:30 | 29-8-21 13:20 | Werder Bremen | FC Hansa Rostock | 3:0 | 2 - 4 punten |
| 29-8-21 13:30 | 29-8-21 13:20 | FC St. Pauli | Jahn Regensburg | 2:0 | 2 - 4 punten |