Speelschema
| Termijn | Voorspellingsdeadline | Thuis | Uitteam | Uitslag | Puntentelling |
|---|---|---|---|---|---|
| 20-8-21 20:30 | 20-8-21 20:28 | RB Leipzig | VfB Stuttgart | 4:0 | 1 - 3 punten |
| 21-8-21 15:30 | 21-8-21 15:28 | SpVgg Greuther Fürth | Arminia Bielefeld | 1:1 | 1 - 3 punten |
| 21-8-21 15:30 | 21-8-21 15:28 | VfL Bochum | FSV Mainz 05 | 2:0 | 1 - 3 punten |
| 21-8-21 15:30 | 21-8-21 15:28 | SC Freiburg | Borussia Dortmund | 2:1 | 1 - 3 punten |
| 21-8-21 15:30 | 21-8-21 15:28 | Eintracht Frankfurt | FC Augsburg | 0:0 | 1 - 3 punten |
| 21-8-21 15:35 | 21-8-21 15:33 | Hertha BSC | VfL Wolfsburg | 1:2 | 1 - 3 punten |
| 21-8-21 18:30 | 21-8-21 18:28 | Bayer 04 Leverkusen | Bor. Mönchengladbach | 4:0 | 1 - 3 punten |
| 22-8-21 15:30 | 22-8-21 15:28 | 1899 Hoffenheim | 1. FC Union Berlin | 2:2 | 1 - 3 punten |
| 22-8-21 17:30 | 22-8-21 17:28 | FC Bayern München | 1. FC Köln | 3:2 | 1 - 3 punten |