Speelschema
| Termijn | Voorspellingsdeadline | Thuis | Uitteam | Uitslag | Puntentelling |
|---|---|---|---|---|---|
| 1-10-21 20:30 | 1-10-21 20:30 | 1. FC Köln | SpVgg Greuther Fürth | 3:1 | 2 - 10 - 10 |
| 2-10-21 15:30 | 2-10-21 15:30 | Hertha BSC | SC Freiburg | 1:2 | 9 - 5 - 3 |
| 2-10-21 15:30 | 2-10-21 15:30 | VfB Stuttgart | 1899 Hoffenheim | 3:1 | 4 - 4 - 4 |
| 2-10-21 15:30 | 2-10-21 15:30 | VfL Wolfsburg | Bor. Mönchengladbach | 1:3 | 3 - 6 - 6 |
| 2-10-21 15:30 | 2-10-21 15:30 | Borussia Dortmund | FC Augsburg | 2:1 | 2 - 10 - 10 |
| 2-10-21 18:30 | 2-10-21 18:30 | RB Leipzig | VfL Bochum | 3:0 | 2 - 10 - 10 |
| 3-10-21 15:30 | 3-10-21 15:30 | FSV Mainz 05 | 1. FC Union Berlin | 1:2 | 3 - 4 - 6 |
| 3-10-21 17:30 | 3-10-21 17:30 | FC Bayern München | Eintracht Frankfurt | 1:2 | 2 - 10 - 10 |
| 3-10-21 19:30 | 3-10-21 19:30 | Arminia Bielefeld | Bayer 04 Leverkusen | 0:4 | 10 - 10 - 2 |