Speelschema
| Termijn | Voorspellingsdeadline | Thuis | Uitteam | Uitslag | Puntentelling |
|---|---|---|---|---|---|
| 17-9-21 20:30 | 17-9-21 20:30 | Hertha BSC | SpVgg Greuther Fürth | 2:1 | 2 - 9 - 8 |
| 18-9-21 15:30 | 18-9-21 15:30 | FC Bayern München | VfL Bochum | 7:0 | 2 - 10 - 10 |
| 18-9-21 15:30 | 18-9-21 15:30 | Arminia Bielefeld | 1899 Hoffenheim | 0:0 | 10 - 5 - 3 |
| 18-9-21 15:30 | 18-9-21 15:30 | FC Augsburg | Bor. Mönchengladbach | 1:0 | 10 - 7 - 2 |
| 18-9-21 15:30 | 18-9-21 15:30 | FSV Mainz 05 | SC Freiburg | 0:0 | 2 - 7 - 8 |
| 18-9-21 18:30 | 18-9-21 18:30 | 1. FC Köln | RB Leipzig | 1:1 | 5 - 5 - 3 |
| 19-9-21 15:30 | 19-9-21 15:30 | VfB Stuttgart | Bayer 04 Leverkusen | 1:3 | 10 - 7 - 2 |
| 19-9-21 17:30 | 19-9-21 17:30 | Borussia Dortmund | 1. FC Union Berlin | 4:2 | 2 - 8 - 10 |
| 19-9-21 19:30 | 19-9-21 19:30 | VfL Wolfsburg | Eintracht Frankfurt | 1:1 | 2 - 7 - 9 |