Speelschema
| Termijn | Voorspellingsdeadline | Thuis | Uitteam | Uitslag | Puntentelling |
|---|---|---|---|---|---|
| 17-12-21 20:30 | 17-12-21 20:30 | FC Bayern München | VfL Wolfsburg | 4:0 | 2 - 10 - 10 |
| 18-12-21 15:30 | 18-12-21 15:30 | 1899 Hoffenheim | Bor. Mönchengladbach | 1:1 | 2 - 7 - 8 |
| 18-12-21 15:30 | 18-12-21 15:30 | Eintracht Frankfurt | FSV Mainz 05 | 1:0 | 3 - 5 - 6 |
| 18-12-21 15:30 | 18-12-21 15:30 | RB Leipzig | Arminia Bielefeld | 0:2 | 2 - 10 - 10 |
| 18-12-21 15:30 | 18-12-21 15:30 | SpVgg Greuther Fürth | FC Augsburg | 0:0 | 7 - 7 - 3 |
| 18-12-21 15:30 | 18-12-21 15:30 | VfL Bochum | 1. FC Union Berlin | 0:1 | 4 - 5 - 3 |
| 18-12-21 18:30 | 18-12-21 18:30 | Hertha BSC | Borussia Dortmund | 3:2 | 10 - 10 - 2 |
| 19-12-21 15:30 | 19-12-21 15:30 | SC Freiburg | Bayer 04 Leverkusen | 2:1 | 3 - 5 - 4 |
| 19-12-21 17:30 | 19-12-21 17:30 | 1. FC Köln | VfB Stuttgart | 1:0 | 3 - 6 - 5 |