Speelschema
| Termijn | Voorspellingsdeadline | Thuis | Uitteam | Uitslag | Puntentelling |
|---|---|---|---|---|---|
| 29-10-21 20:30 | 29-10-21 20:30 | 1899 Hoffenheim | Hertha BSC | 2:0 | 3 - 7 - 6 |
| 30-10-21 15:30 | 30-10-21 15:30 | Arminia Bielefeld | FSV Mainz 05 | 1:2 | 10 - 10 - 2 |
| 30-10-21 15:30 | 30-10-21 15:30 | SC Freiburg | SpVgg Greuther Fürth | 3:1 | 2 - 10 - 10 |
| 30-10-21 15:30 | 30-10-21 15:30 | 1. FC Union Berlin | FC Bayern München | 2:5 | 10 - 6 - 2 |
| 30-10-21 15:30 | 30-10-21 15:30 | Bayer 04 Leverkusen | VfL Wolfsburg | 0:2 | 2 - 8 - 7 |
| 30-10-21 15:30 | 30-10-21 15:30 | Borussia Dortmund | 1. FC Köln | 2:0 | 2 - 6 - 10 |
| 30-10-21 18:30 | 30-10-21 18:30 | Eintracht Frankfurt | RB Leipzig | 1:1 | 6 - 6 - 3 |
| 31-10-21 15:30 | 31-10-21 15:30 | FC Augsburg | VfB Stuttgart | 4:1 | 7 - 7 - 3 |
| 31-10-21 17:30 | 31-10-21 17:30 | Bor. Mönchengladbach | VfL Bochum | 2:1 | 2 - 6 - 10 |