| Termijn | Thuis | Uitteam | Uitslag |
|---|---|---|---|
| 21-1-25 16:30 | Galatasaray Istanbul | Dynamo Kiew | 3:3 |
| 22-1-25 16:30 | Besiktas Istanbul | Athletic Bilbao | -:- |
| 23-1-25 18:45 | AZ Alkmaar | AS Rom | -:- |
| 23-1-25 18:45 | Malmö FF | FC Twente Enschede | -:- |
| 23-1-25 18:45 | FK Bodö/Glimt | Maccabi Tel Aviv | -:- |
| 23-1-25 18:45 | Qarabag | FCSB Bukarest | -:- |
| 23-1-25 18:45 | Viktoria Pilsen | RSC Anderlecht | -:- |
| 23-1-25 18:45 | 1899 Hoffenheim | Tottenham Hotspur | -:- |
| 23-1-25 18:45 | FC Porto | Olympiakos Piräus | -:- |
| 23-1-25 18:45 | Fenerbahce Istanbul | Olympique Lyon | -:- |
| 23-1-25 21:00 | Rigas Futbola Skola | Ajax Amsterdam | -:- |
| 23-1-25 21:00 | PFC Ludogorets Razgrad | FC Midtjylland | -:- |
| 23-1-25 21:00 | Royale Union Saint-Gilloise | Sporting Braga | -:- |
| 23-1-25 21:00 | IF Elfsborg Boras | OGC Nice | -:- |
| 23-1-25 21:00 | Eintracht Frankfurt | Ferencvárosi TC | -:- |
| 23-1-25 21:00 | Manchester United | Glasgow Rangers | -:- |
| 23-1-25 21:00 | Lazio Rom | Real Sociedad | -:- |
| 23-1-25 21:00 | PAOK Saloniki | Slavia Prag | -:- |