Speelschema
| Termijn | Voorspellingsdeadline | Thuis | Uitteam | Uitslag | Puntentelling |
|---|---|---|---|---|---|
| 15-10-21 20:30 | 15-10-21 20:30 | 1899 Hoffenheim | 1. FC Köln | 5:0 | 3 - 4 - 5 |
| 16-10-21 15:30 | 16-10-21 15:30 | 1. FC Union Berlin | VfL Wolfsburg | 2:0 | 4 - 3 - 4 |
| 16-10-21 15:30 | 16-10-21 15:30 | Eintracht Frankfurt | Hertha BSC | 1:2 | 2 - 6 - 8 |
| 16-10-21 15:30 | 16-10-21 15:30 | Borussia Dortmund | FSV Mainz 05 | 3:1 | 2 - 8 - 8 |
| 16-10-21 15:30 | 16-10-21 15:30 | SpVgg Greuther Fürth | VfL Bochum | 0:1 | 4 - 3 - 4 |
| 16-10-21 15:30 | 16-10-21 15:30 | SC Freiburg | RB Leipzig | 1:1 | 6 - 4 - 3 |
| 16-10-21 18:30 | 16-10-21 18:30 | Bor. Mönchengladbach | VfB Stuttgart | 1:1 | 2 - 8 - 8 |
| 17-10-21 15:30 | 17-10-21 15:30 | Bayer 04 Leverkusen | FC Bayern München | 1:5 | 7 - 5 - 2 |
| 17-10-21 17:30 | 17-10-21 17:30 | FC Augsburg | Arminia Bielefeld | 1:1 | 3 - 4 - 6 |