Speelschema
| Termijn | Voorspellingsdeadline | Thuis | Uitteam | Uitslag | Puntentelling |
|---|---|---|---|---|---|
| 11-9-21 15:30 | 11-9-21 15:30 | SpVgg Greuther Fürth | VfL Wolfsburg | 0:2 | 8 - 8 - 2 |
| 11-9-21 15:30 | 11-9-21 15:30 | 1899 Hoffenheim | FSV Mainz 05 | 0:2 | 2 - 5 - 6 |
| 11-9-21 15:30 | 11-9-21 15:30 | SC Freiburg | 1. FC Köln | 1:1 | 3 - 5 - 5 |
| 11-9-21 15:30 | 11-9-21 15:30 | 1. FC Union Berlin | FC Augsburg | 0:0 | 2 - 6 - 8 |
| 11-9-21 15:30 | 11-9-21 15:30 | Bayer 04 Leverkusen | Borussia Dortmund | 3:4 | 4 - 4 - 3 |
| 11-9-21 18:30 | 11-9-21 18:30 | RB Leipzig | FC Bayern München | 1:4 | 6 - 6 - 2 |
| 12-9-21 15:30 | 12-9-21 15:30 | Eintracht Frankfurt | VfB Stuttgart | 1:1 | 3 - 4 - 6 |
| 12-9-21 17:30 | 12-9-21 17:30 | VfL Bochum | Hertha BSC | 1:3 | 4 - 4 - 4 |
| 12-9-21 19:30 | 12-9-21 19:30 | Bor. Mönchengladbach | Arminia Bielefeld | 3:1 | 2 - 8 - 8 |