Speelschema
| Termijn | Voorspellingsdeadline | Thuis | Uitteam | Uitslag | Puntentelling |
|---|---|---|---|---|---|
| 8-4-22 20:30 | 8-4-22 20:30 | VfB Stuttgart | Borussia Dortmund | 0:2 | 6 - 7 - 2 |
| 9-4-22 15:30 | 9-4-22 15:30 | 1. FC Köln | FSV Mainz 05 | 3:2 | 3 - 4 - 4 |
| 9-4-22 15:30 | 9-4-22 15:30 | VfL Wolfsburg | Arminia Bielefeld | 4:0 | 2 - 6 - 8 |
| 9-4-22 15:30 | 9-4-22 15:30 | FC Bayern München | FC Augsburg | 1:0 | 2 - 8 - 8 |
| 9-4-22 15:30 | 9-4-22 15:30 | SpVgg Greuther Fürth | Bor. Mönchengladbach | 0:2 | 8 - 7 - 2 |
| 9-4-22 18:30 | 9-4-22 18:30 | Hertha BSC | 1. FC Union Berlin | 1:4 | 4 - 4 - 4 |
| 10-4-22 15:30 | 10-4-22 15:30 | VfL Bochum | Bayer 04 Leverkusen | 0:0 | 7 - 6 - 2 |
| 10-4-22 17:30 | 10-4-22 17:30 | Eintracht Frankfurt | SC Freiburg | 1:2 | 4 - 4 - 3 |
| 10-4-22 19:30 | 10-4-22 19:30 | RB Leipzig | 1899 Hoffenheim | 3:0 | 2 - 8 - 8 |