Speelschema
| Termijn | Voorspellingsdeadline | Thuis | Uitteam | Uitslag | Puntentelling |
|---|---|---|---|---|---|
| 16-10-21 13:30 | 16-10-21 13:29 | FC Watford | FC Liverpool | 0:5 | 2 - 4 punten |
| 16-10-21 16:00 | 16-10-21 15:59 | Aston Villa | Wolverhampton Wanderers | 2:3 | 2 - 4 punten |
| 16-10-21 16:00 | 16-10-21 15:59 | Leicester City | Manchester United | 4:2 | 2 - 4 punten |
| 16-10-21 16:00 | 16-10-21 15:59 | Manchester City | FC Burnley | 2:0 | 2 - 4 punten |
| 16-10-21 16:00 | 16-10-21 15:59 | Norwich City | Brighton and Hove Albion | 0:0 | 2 - 4 punten |
| 16-10-21 16:00 | 16-10-21 15:59 | FC Southampton | Leeds United | 1:0 | 2 - 4 punten |
| 16-10-21 18:30 | 16-10-21 18:29 | Brentford FC | FC Chelsea | 0:1 | 2 - 4 punten |
| 17-10-21 15:00 | 17-10-21 14:59 | FC Everton | West Ham United | 0:1 | 2 - 4 punten |
| 17-10-21 17:30 | 17-10-21 17:29 | Newcastle United | Tottenham Hotspur | 2:3 | 2 - 4 punten |
| 18-10-21 21:00 | 18-10-21 20:59 | FC Arsenal | Crystal Palace | 2:2 | 2 - 4 punten |