Speelschema
| Termijn | Voorspellingsdeadline | Thuis | Uitteam | Uitslag | Puntentelling |
|---|---|---|---|---|---|
| 17-9-21 21:00 | 17-9-21 20:59 | Newcastle United | Leeds United | 1:1 | 2 - 4 punten |
| 18-9-21 13:30 | 18-9-21 13:29 | Wolverhampton Wanderers | Brentford FC | 0:2 | 2 - 4 punten |
| 18-9-21 16:00 | 18-9-21 15:59 | FC Burnley | FC Arsenal | 0:1 | 2 - 4 punten |
| 18-9-21 16:00 | 18-9-21 15:59 | FC Liverpool | Crystal Palace | 3:0 | 2 - 4 punten |
| 18-9-21 16:00 | 18-9-21 15:59 | Manchester City | FC Southampton | 0:0 | 2 - 4 punten |
| 18-9-21 16:00 | 18-9-21 15:59 | Norwich City | FC Watford | 1:3 | 2 - 4 punten |
| 18-9-21 18:30 | 18-9-21 18:29 | Aston Villa | FC Everton | 3:0 | 2 - 4 punten |
| 19-9-21 15:00 | 19-9-21 14:59 | West Ham United | Manchester United | 1:2 | 2 - 4 punten |
| 19-9-21 15:00 | 19-9-21 14:59 | Brighton and Hove Albion | Leicester City | 2:1 | 2 - 4 punten |
| 19-9-21 17:30 | 19-9-21 17:29 | Tottenham Hotspur | FC Chelsea | 0:3 | 2 - 4 punten |