Speelschema
| Termijn | Voorspellingsdeadline | Thuis | Uitteam | Uitslag | Puntentelling |
|---|---|---|---|---|---|
| 4-12-21 13:30 | 4-12-21 13:29 | West Ham United | FC Chelsea | 3:2 | 2 - 4 punten |
| 4-12-21 16:00 | 4-12-21 15:59 | Newcastle United | FC Burnley | 1:0 | 2 - 4 punten |
| 4-12-21 16:00 | 4-12-21 15:59 | FC Southampton | Brighton and Hove Albion | 1:1 | 2 - 4 punten |
| 4-12-21 16:00 | 4-12-21 15:59 | Wolverhampton Wanderers | FC Liverpool | 0:1 | 2 - 4 punten |
| 4-12-21 18:30 | 4-12-21 18:29 | FC Watford | Manchester City | 1:3 | 2 - 4 punten |
| 5-12-21 15:00 | 5-12-21 14:59 | Leeds United | Brentford FC | 2:2 | 2 - 4 punten |
| 5-12-21 15:00 | 5-12-21 14:59 | Manchester United | Crystal Palace | 1:0 | 2 - 4 punten |
| 5-12-21 15:00 | 5-12-21 14:59 | Tottenham Hotspur | Norwich City | 3:0 | 2 - 4 punten |
| 5-12-21 17:30 | 5-12-21 17:29 | Aston Villa | Leicester City | 2:1 | 2 - 4 punten |
| 6-12-21 21:00 | 6-12-21 20:59 | FC Everton | FC Arsenal | 2:1 | 2 - 4 punten |