Speelschema
| Termijn | Voorspellingsdeadline | Thuis | Uitteam | Uitslag | Puntentelling |
|---|---|---|---|---|---|
| 13-8-21 18:30 | 13-8-21 18:30 | FC Schalke 04 | Erzgebirge Aue | 1:1 | 2 - 4 punten |
| 13-8-21 18:30 | 13-8-21 18:30 | FC St. Pauli | Hamburger SV | 3:2 | 2 - 4 punten |
| 14-8-21 13:30 | 14-8-21 13:30 | Holstein Kiel | Jahn Regensburg | 0:3 | 2 - 4 punten |
| 14-8-21 13:30 | 14-8-21 13:30 | 1. FC Nürnberg | Fortuna Düsseldorf | 2:0 | 2 - 4 punten |
| 14-8-21 13:30 | 14-8-21 13:30 | SV Sandhausen | Karlsruher SC | 0:0 | 2 - 4 punten |
| 14-8-21 20:30 | 14-8-21 20:30 | Dynamo Dresden | Hannover 96 | 2:0 | 2 - 4 punten |
| 15-8-21 13:30 | 15-8-21 13:30 | Werder Bremen | SC Paderborn 07 | 1:4 | 2 - 4 punten |
| 15-8-21 13:30 | 15-8-21 13:30 | SV Darmstadt 98 | FC Ingolstadt | 6:1 | 2 - 4 punten |
| 15-8-21 13:30 | 15-8-21 13:30 | 1. FC Heidenheim 1846 | FC Hansa Rostock | 1:1 | 2 - 4 punten |