| Termijn | Voorspellingsdeadline | Thuis | Uitteam | Uitslag | Puntentelling |
|---|---|---|---|---|---|
| 3-12-21 20:30 | 3-12-21 20:30 | 1. FC Union Berlin | RB Leipzig | 2:1 | 2 - 4 punten |
| 4-12-21 15:30 | 4-12-21 15:30 | FSV Mainz 05 | VfL Wolfsburg | 3:0 | 2 - 4 punten |
| 4-12-21 15:30 | 4-12-21 15:30 | 1899 Hoffenheim | Eintracht Frankfurt | 3:2 | 2 - 4 punten |
| 4-12-21 15:30 | 4-12-21 15:30 | Bayer 04 Leverkusen | SpVgg Greuther Fürth | 7:1 | 2 - 4 punten |
| 4-12-21 15:30 | 4-12-21 15:30 | Arminia Bielefeld | 1. FC Köln | 1:1 | 2 - 4 punten |
| 4-12-21 15:30 | 4-12-21 15:30 | FC Augsburg | VfL Bochum | 2:3 | 2 - 4 punten |
| 4-12-21 18:30 | 4-12-21 18:30 | Borussia Dortmund | FC Bayern München | 2:3 | 2 - 4 punten |
| 5-12-21 15:30 | 5-12-21 15:30 | VfB Stuttgart | Hertha BSC | 2:2 | 2 - 4 punten |
| 5-12-21 17:30 | 5-12-21 17:30 | Bor. Mönchengladbach | SC Freiburg | 0:6 | 2 - 4 punten |